: Scientists use human breast milk to treat prolonged Covid #IndiaNEWS #Health Sao Paulo: In a rare case, Brazilian scientists used breast milk to treat Covid-19 in a woman with a rare genetic disease

Scientists use human breast milk to treat prolonged Covid #IndiaNEWS #Health
Sao Paulo: In a rare case, Brazilian scientists used breast milk to treat Covid-19 in a woman with a rare genetic disease that makes her immune system unable to combat viruses and other pathogens.
The patient who was diagnosed with Covid-19, in March 2021, tested positive for 124 days by RT-PCR. She was advised by the team from the University of Campinas (UNICAMP) in Sao Paulo, to take 30 millilitres of breast milk every three hours for a week. The breast milk was donated by a woman who had been vaccinated against SARS-CoV-2.
The breast milk improved her immunity levels and helped her test negative within a week, according to the case reported in an article published in the journal Viruses.
Ive followed this patient since she was a child, and I was very concerned when she told me she had Covid-19. The innate immunity error from which she suffers dysregulates her entire defence system. Her inflammatory response is defective, with few cells going to the site of the inflammation and low antibody production. Depending on their virulence, infectious agents can lead to two outcomes in such cases chronic infection or death, said paediatrician Maria Marluce dos Santos Vilela, a professor at UNICAMPs Medical School.
Vilela explained that the immune system in humans and other mammals normally produces five types of immunoglobulin antibody (IgM, IgG, IgA, IgE and IgD).
Patients with immune dysregulation syndromes have a deficiency of IgE and in some cases a complete absence of IgA, the main antibody that neutralises viruses and other pathogens. IgA is usually present in breast milk, as well as respiratory and gastrointestinal secretions.
The syndromes also entail very low production of IgG, normally the most abundant antibody in blood and responsible for recognising and neutralising antigens with which the organism has had contact before.
Only 157 cases of the same kind as this patients have been described worldwide, as reported in an article published in the Journal of Allergy and Clinical Immunology.
Vilela said the patient was deliberately treated at home to avoid hospital-related bacterial infection, which would have made her condition much worse.
In the first 15 days of the infection, the patient had fever, loss of appetite, coughing and asthenia (lack of energy, weakness), but to Vilelas surprise and relief, her lungs and other systems remained unaffected. After two months, her condition was the same, and the researchers decided to treat her with convalescent plasma.
The treatment entails a transfusion of IgG and other antibodies produced by people who have recovered from Covid.
While her symptoms improved, with a reduction in blood inflammatory markers, after the procedure, her RT-PCR test remained positive even after 15 days.

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