: Research finds reason for return of brain cancer #IndiaNEWS #Features Washington: According to researchers working to develop a cure for brain cancer, the deadliest type of the disease returns because

Research finds reason for return of brain cancer #IndiaNEWS #Features
Washington: According to researchers working to develop a cure for brain cancer, the deadliest type of the disease returns because tumours adapt to therapy by recruiting help from nearby healthy tissue.
A new study, by a global team including University of Leeds experts, has found that in response to treatment, high-grade gliomas appear to remodel the surrounding brain environment, potentially creating interactions with nearby neurons and immune cells in ways that protect the tumour cells and hide them from the bodys defences.
The team also found that lower-grade tumours often develop a new mutation that allows the cells to start dividing more rapidly, potentially catapulting them into a higher-grade form.
Glioma brain tumours are rare, but a diagnosis is devastating because there is currently no cure. Low-grade gliomas have a better survival rate but often progress to high-grade gliomas. More than 90 per cent of patients with high-grade tumours die within five years.
Current treatments include surgery, radiation therapy and chemotherapy. The findings indicate that new drugs are needed to supplement these.
Dr Lucy Stead, Associate Professor of Brain Cancer Biology in the University of Leeds School of Medicine, and the lead UK academic for the study, said: The brain is a hugely complex organ made up of lots of different types of cells, and brain tumours are equally diverse and complicated.
Learning from patient tissue is the best way to cure the patient disease. This study, which required a global effort to acquire enough glioma samples to adequately power it, has allowed us to gain unprecedented insight into how these deadly tumours progress, and ways that we might finally be able to stop them. Sue, a brain tumour patient from York, died in September 2017 after a seven-year battle with the disease. Her husband of 50 years, Geoff, is now an ambassador for Yorkshires Brain Tumour Charity, taking part in events to help raise funds for brain cancer research and awareness.
Welcoming the findings, he said: Sue fought bravely and without a single word of complaint or self-pity for 7 years. This is my driver. The types and positions of tumours make this a difficult one to actually solve. But it is a scandal that the survival rate for brain tumours is no better now than 40 years ago.
It seems from my experience that a one size fits all approach is applied to treatment at the moment and any form of targeting treatment specifically to suit the person must be an improvement. The fact that research is being undertaken has also a beneficial effect on patients and their families. It generates hope. The researchers are investigating why gliomas progress to a higher-grade form, and why they survive and continue to grow after treatment.

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